| 1:00 PM EDT |
| 401 TENNESSEE TITANS | 37.5 | 37.5 / 37 / 36.5 | 36 | +110 | | 17 Over 36 0 |
| 402 NEW YORK JETS | -3 +05 | -2 / -1.5 / -1 | -1 -05 | -130 | | 24 final 0 |
| TEN-TE-Sciafe, K-Bironas-Questionable; P-Hentrich-DoubtfulNYJ-LB-Pace-Suspended |
|
| 1:00 PM EDT |
| 403 JACKSONVILLE JAGUARS | 46o10 | 47 / 46.5 / 47 | 47.5 | +175 | | 31 Over 47.5 0 |
| 404 HOUSTON TEXANS | -3.5 -15 | -3.5 / -3.5 -15 / -4 | -4.5 | -210 | | 24 final 0 |
| HOU-WR-Walter-Probable, A. Davis-Doubtful |
|
| 1:00 PM EDT |
| 405 KANSAS CITY CHIEFS | 42 | 39.5 / 40 / 39.5 | 39 | +260 | | 14 Over 39 0 |
| 406 PHILADELPHIA EAGLES | -9 +11 | -8 / -7.5 / -7 | -7.5 | -320 | | 34 final 0 |
| GAME CIRCLED KC-WR-Bowe, TE-O''Connell-Questionable; PHI-QB-McNabb-Doubtful; RB-Westbrook-Expected to Miss, WR-Jackson-ProbablePHI-QB-Vick-returns from suspension |
|
| 1:00 PM EDT |
| 407 CLEVELAND BROWNS | 39 | 39 / 38.5 / 38 | 38.5 | +600 | | 3 Under 38.5 0 |
| 408 BALTIMORE RAVENS | -13 | -13 / -13 -05 / -13.5 -05 | -13.5 | -800 | | 34 final 0 |
| CLE-RB-Jamal Lewis, K-Dawson-OUT; K-Cundiff-signedBAL-CB-Rolle-OUT; S-Reed-Questionable |
|
| 1:00 PM EDT |
| 409 NEW YORK GIANTS | -7 -02 | -6.5 -15 / -7 -05 / -6.5 -15 | -6.5 | -270 | | 24 Under 46 0 |
| 410 TAMPA BAY BUCCANEERS | 43o10 | 45.5 / 46 / 45.5 | 46 | +230 | | 0 final 0 |
| NY-WR-Hixon, DE-Tuck-both OUT; WR-Manningham-QuestionableTB-WR-Bryant-Doubtful |
|
| 1:00 PM EDT |
| 411 WASHINGTON REDSKINS | -6.5 | -6.5 / -6.5 -05 / -6.5 | -6 | -260 | | 14 Under 39.5 0 |
| 412 DETROIT LIONS | 38.5 | 38.5 / 39 | 39.5 | +220 | | 19 final 0 |
| WAS-QB-Campbell, RB-Portis-Probable |
|
| 1:00 PM EDT |
| 413 GREEN BAY PACKERS | -6.5 -05 | -6.5 / -6.5 -05 / -6.5 | -6.5 -15 | -275 | | 36 Over 43 0 |
| 414 ST. LOUIS RAMS | 40.5u07 | 41.5 / 42 / 42.5 | 43 | +235 | | 17 final 0 |
| GB-RB-B.Jackson-OUTSTL-OLs-J.Smith-OUT; Brown, Barron-Probable |
|
| 1:00 PM EDT |
| 415 SAN FRANCISCO 49ERS | 40.5o10 | 40 / 39.5 / 39 | 39.5 | +230 | | 24 Over 39.5 0 |
| 416 MINNESOTA VIKINGS | -6.5 -07 | -6.5 / -6.5 -05 / -7 -05 | -7 | -270 | | 27 final 0 |
| SF-RB-Gore-ProbableMIN-RB-Peterson-Probable; WR-Havin-Questionable |
|
| 1:00 PM EDT |
| 417 ATLANTA FALCONS | 45u10 | 47 / 46.5 / 46 | 45.5 | +180 | | 10 Under 45.5 0 |
| 418 NEW ENGLAND PATRIOTS | -4.5 EVEN | -4.5 -05 / -4.5 / -5 | -4.5 | -220 | | 26 final 0 |
| ATL-RB-Norwood-DoubtfulNE-WR-Welker-Out, WR-Moss-Probable |
|
| 4:05 PM EDT |
| 419 CHICAGO BEARS | -1 | -2 / -2.5 / -2.5 -15 | -2.5 -20 | -145 | | 25 Over 37.5 0 |
| 420 SEATTLE SEAHAWKS | 37u08 | 37u08 / 37 | 37.5 | +125 | | 19 final 0 |
| CHI-TE-Clark-DoubtfulSEA-QB-Hasselbeck-OUT, WR-Branch, RB-J. Jones-Both Probable |
|
| 4:05 PM EDT |
| 421 NEW ORLEANS SAINTS | -4 -07 | -6 / -6 -05 / -6 | -5.5 | -240 | | 27 Under 51.5 0 |
| 422 BUFFALO BILLS | 52o07 | 52 / 51.5 / 51 | 51.5 | +200 | | 7 final 0 |
| NO-RB-Thomas-Probable; RB-Bell-OUT; WR-Moore-OUTBUF-TE-Schouman-OUT; RB-Lynch-Suspended; WR-Reed-Questionable |
|
| 4:15 PM EDT |
| 423 MIAMI DOLPHINS | 43u07 | 44 / 44.5 / 45 | 45.5 | +200 | | 13 Under 45.5 0 |
| 424 SAN DIEGO CHARGERS | -6.5 -04 | -5.5 -05 / -6 -05 / -6 | -5.5 | -240 | | 23 final 0 |
| MIA-LB-Porter-ProbableSD-RB-Tomlinson-OUT; LB-Merriman-ProbableSD-NT-J.Williams-OUT; DT-T.Johnson-OUT |
|
| 4:15 PM EDT |
| 425 PITTSBURGH STEELERS | -4.5 | -4 -05 / -3.5 -05 / -3.5 | -3.5 -05 | -180 | | 20 Over 37 0 |
| 426 CINCINNATI BENGALS | 37 | 37 / 37.5 / 36.5 | 37 | +160 | | 23 final 0 |
| PIT-WRs-Holmes, Sweed-Probable; S-Polamalu-OUT |
|
| 4:15 PM EDT |
| 427 DENVER BRONCOS | 36.5 | -1.5 -05 / -1.5 / -2 | -2.5 | -135 | | 23 Under 38 0 |
| 428 OAKLAND RAIDERS | -2.5 | 37.5 / 38 / 38.5 | 38 | +115 | | 3 final 0 |
| DEN-WR-Stokley, RB-Moreno-both gametime decisionsOAK-WR-Higgins-Probable; RB-Fargas-Probable (healthy inactive wk2) |
|
| 8:20 PM EDT |
| 429 INDIANAPOLIS COLTS | 48u08 | 47.5 / 48 / 48.5 | 49 | +140 | | 31 Under 49 0 |
| 430 ARIZONA CARDINALS | -1 -16 | -3 -05 / -3 / -3 -15 | -3 -20 | -160 | | 10 final 0 |
| NBCIND-WR-Gonzalez, WR-Sanders-OUT; DE-Freeney-ProbableARZ-WR-Boldin-Probable, WR-Breaston-Probable |
|
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